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目的探讨新生儿窒息后心率变异性的改变及其临床意义。方法应用美国CompasXMHolter分析系统检测22例窒息新生儿和21例正常新生儿的心率变异性。结果新生儿窒息后早期及恢复期24h窦性RR间期标准差（SDNN）、每5min窦性RR间期标准差的均值（SDNNI）、心率变异性指数（HRVI）与对照组比较显著降低（P＜0．05）。SDNN、SDNNIDX、HRVI与24h最慢心率负相关（r＝－0．43～－0．57，P＜0．01），SDNNIDX与24h最快心率正相关（r＝0．29，P＜0．05）。结论新生儿窒息后心脏自主神经功能受损并影响心率的改变。心率变异性参数是判断新生儿窒息后心肌损害较稳定的指标。
Objective To investigate the changes of heart rate variability after neonatal asphyxia and its clinical significance. Methods The American CompasXMHolter analysis system was used to detect heart rate variability in 22 neonates with asphyxia and 21 normal neonates. Results SDNN, SDNNI and HRVI of sinus RR interval at 5 min after neonatal asphyxia were significantly lower than those of the control group (P <0.05) P <0.05). SDNN, SDNNIDX and HRVI were negatively correlated with the lowest heart rate at 24 hours (r = -0.43-0.57, P <0.01). SDNNIDX was positively correlated with the fastest heart rate at 24 hours (r = 0.29, P <0 .05). Conclusion Neonatal asphyxia impaired cardiac autonomic nervous function and influenced the change of heart rate. Heart rate variability parameters to determine neonatal asphyxia myocardial damage more stable indicators.