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目的探讨米非司酮联合甲氨喋呤治疗异位妊娠的疗效及不良反应。方法将50例异位妊娠患者随机分为米非司酮联合甲氨喋呤治疗组(治疗组)和单用甲氨蝶呤治疗组(对照组),对两组疗效及不良反应进行比较。结果治疗组成功率92%,对照组成功率76%,两组比较差异有统计学意义(P<0.05)。治疗组血β人绒毛膜促性腺激素(β-HCG)值在用药后5d开始下降,对照组于用药后10d开始明显下降,两组比较差异有统计学意义(P<0.05)。治疗组不良反应发生率明显低于对照组(P<0.05)。结论米非司酮联合甲氨喋呤治疗异位妊娠安全有效。
Objective To investigate the efficacy and adverse reactions of mifepristone combined with methotrexate in the treatment of ectopic pregnancy. Methods 50 cases of ectopic pregnancy were randomly divided into mifepristone combined with methotrexate treatment group (treatment group) and methotrexate alone group (control group), the two groups were compared efficacy and adverse reactions. Results The success rate of treatment group was 92% and that of control group was 76%. There was significant difference between the two groups (P <0.05). The value of β-HCG in treatment group began to decrease 5 days after treatment, while the control group began to decrease significantly 10 days after treatment. The difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P <0.05). Conclusion The combination of mifepristone and methotrexate is safe and effective in the treatment of ectopic pregnancy.