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目的:探讨乳腺癌方对乳腺癌术后生存质量及趋化因子受体(CXCR7)、细胞核因子B(NF-κB)表达水平的影响。方法:将乳腺癌根治术患者76例随机分为2组各38例,对照组术前不用中药治疗,观察组术前予以乳腺癌方治疗,评定乳腺癌生存质量评分(Euro QLQ-BR23)和主要症状评分,记录2组CXCR7、NF-κB表达水平的变化;随访1年,记录2组生存率、疾病转移复发率。结果:治疗后观察组生存质量评分较治疗前升高(P<0.05),症状疲乏无力、恶心呕吐、食欲不振、睡眠障碍等评分较治疗前降低(P<0.05)。治疗3月后,观察组CXCB7蛋白、NF-κB阳性表达率分别为31.58%、36.84%,对照组分别为57.89%、63.16%,2组比较,差异有统计学意义(P<0.05)。1年转移复发率观察组为2.63%,对照组为15.79%,2组比较,差异有统计学意义(P<0.05)。2组1年生存率比较,差异无统计学意义(P>0.05)。结论:乳腺癌根治术前予以乳腺癌方治疗,能够改善患者不适症状,降低CXCR7蛋白及NF-κB水平表达率,提高患者生存质量。
Objective: To investigate the effect of breast cancer on the postoperative quality of life and the expression of chemokine receptor (CXCR7) and nuclear factor B (NF-κB) in breast cancer. Methods: 76 patients with radical mastectomy were randomly divided into two groups (n = 38). The control group was treated with no traditional Chinese medicine before operation. The observation group was given preoperative breast cancer treatment and the quality of life of breast cancer score (Euro QLQ-BR23) The main symptom scores were recorded, and the changes of CXCR7 and NF-κB expression were recorded in two groups. After one year follow-up, the survival rate of two groups and the recurrence rate of disease were recorded. Results: After treatment, the QOL scores of the observation group were significantly higher than those before treatment (P <0.05). The symptoms such as fatigue, nausea and vomiting, loss of appetite and sleep disturbance decreased significantly (P <0.05). After 3 months of treatment, the positive rates of CXCB7 protein and NF-κB in the observation group were 31.58% and 36.84% respectively, while those in the control group were 57.89% and 63.16% respectively. There was significant difference between the two groups (P <0.05). The recurrence rate in one year was 2.63% in the observation group and 15.79% in the control group. There was significant difference between the two groups (P <0.05). There was no significant difference in one-year survival rate between the two groups (P> 0.05). Conclusion: Breast cancer treatment before radical mastectomy can improve the symptoms of patients, reduce the expression of CXCR7 protein and NF-κB, and improve the quality of life of patients.