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目的分析登革热实验室检测病毒核酸、血清丙二醛(MDA)、血常规的特点。方法统计2014年9-10月广东省中医院收治的60例疑似登革热患者的临床及实验室检查结果,采用PCR荧光探针法检测患者的登革病毒核酸,ELISA法进行MDA检测,联合血常规检测进行结果分析。结果本次登革热流行临床表现典型,以高热、疲乏、骨骼肌肉酸痛、皮疹为多见。实验室检测结果为登革热核酸阳性数40例,登革热核酸阴性20例。血清MDA含量在登革热核酸阳性组高于阴性对照组[(2.13±5.41)mmol/L vs(0.99±0.70)mmol/L],男性阳性组高于男性对照组[(3.04±7.22)mmol/L vs(0.97±0.77)mmol/L],女性阳性组高于女性对照组[(1.02±0.68)mmol/L vs(1.01±0.64)mmol/L],但差异均无统计学意义(P>0.05)。白细胞减少21例,血小板减少20例。结论临床特征明显,白细胞、血小板减少为典型表现,开展MDA检测具有良好的应用前景。
Objective To analyze the characteristics of dengue fever laboratory virus nucleic acid, serum malondialdehyde (MDA) and blood routine. Methods The clinical and laboratory results of 60 suspected dengue patients treated in Guangdong Provincial Hospital of Traditional Chinese Medicine from September to October 2014 were analyzed. PCR was used to detect dengue virus nucleic acid in patients. ELISA was used to detect MDA, Test results analysis. Results The clinical manifestations of dengue epidemic typical, with high fever, fatigue, skeletal muscle soreness, rash is more common. Laboratory tests showed that there were 40 cases of positive dengue nucleic acid and 20 cases of negative dengue nucleic acid. The level of MDA in the positive group was higher than that in the negative control group [(2.13 ± 5.41) mmol / L vs (0.99 ± 0.70) mmol / L], and higher in the male positive group than in the male control group [(3.04 ± 7.22) mmol / L (0.97 ± 0.77) mmol / L], and the positive rate in female group was significantly higher than that in female control group [(1.02 ± 0.68) mmol / L vs (1.01 ± 0.64) mmol / L] ). 21 cases of leukopenia, thrombocytopenia in 20 cases. Conclusion The clinical features are obvious, leukopenia and thrombocytopenia are the typical manifestations, and the detection of MDA has a good prospect of application.