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目的 :初步明确家族性热性惊厥 (FC)相关基因在染色体上的定位。方法 :对 10个家系进行染色体 6 p和 8q上5个标记 (1个RFLP位点 ,4个长度多态性 )的基因分型 ,用PPAP软件计算Lod值。结果 :6号染色体上标记和FC之间最大Lod值为 0 .5 4,8号染色体为 0 .88。结论 :提示家族性热性惊厥与 6 p和 8q关联 ,但不支持与这些位点连锁。
Objective: To clarify the location of familial febrile seizure (FC) related genes in chromosomes. Methods: Genotyping was performed on 10 pedigrees with 5 markers (1 RFLP locus and 4 length polymorphisms) on chromosomes 6 p and 8 q, and Lod values were calculated by PPAP software. RESULTS: The maximum Lod value between marker and FC on chromosome 6 was 0.55 and chromosomes 8 and 8 were 0.88. Conclusions: It is suggested that familial febrile seizures are associated with 6p and 8q, but not with these sites.