自噬是在相关基因的调控下,自噬细胞溶酶体依赖性的降解细胞内受损的细胞器及大分子物质的过程。肥胖个体下丘脑、脂肪组织自噬水平改变,自噬参与了下丘脑控制进食及能量平衡调节,并且与脂肪细胞的分化、脂肪形成有关。自噬与肥胖发生的关系日益受到重视,为肥胖的发病机制研究及治疗提供了新的方向。 Autophagy is the process of lysosome-dependent degradation of intracellular organelles and macromolecular substances by autophagic cells under the control of related genes. Obese individuals hypothalamus, adipose tissue autophagy levels change, autophagy involved in hypothalamic control of food intake and energy balance regulation, and adipocyte differentiation, adipogenesis. The relationship between autophagy and obesity has been paid more and more attention, which provides a new direction for the study and treatment of the pathogenesis of obesity.