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目的探究三维适形放疗同步化疗治疗中晚期食管癌患者的临床疗效和安全性。方法选取本院2008年1月到2009年1月之间收录的60例中晚期食管癌患者,并采取三维适形放疗同步化疗治疗,观察治疗效果。结果通过分析,治疗有效率为91.7%,其中,CR为33.3%,PR为58.3%,ND为3.3%,PD为5.0%。在随访的1年、2年后的局部控制率为81.7%、75.0%;生存率为85.0%、78.3%。而毒副反应中出现白细胞下降和血小板下降以及急性放射性食管炎,主要以Ⅰ～Ⅱ度为主。结论临床中对于中晚期食管癌患者采取三维适形放疗同步化疗治疗具有较好的临床疗效,而且有效的提高患者的生存率,虽然出现有毒副反应,但是程度较轻,患者能够耐受治疗。
Objective To investigate the clinical efficacy and safety of three-dimensional conformal radiotherapy with concurrent chemotherapy in patients with advanced esophageal cancer. Methods Sixty patients with advanced esophageal cancer who were included in our hospital from January 2008 to January 2009 were selected and treated with three-dimensional conformal radiotherapy and concurrent chemotherapy. The therapeutic effect was observed. Results The analysis showed that the effective rate of treatment was 91.7%, of which CR was 33.3%, PR was 58.3%, ND was 3.3% and PD was 5.0%. At 1 year of follow-up, the local control rates after 2 years were 81.7% and 75.0%; the survival rates were 85.0% and 78.3% respectively. The toxic side effects of leukopenia and thrombocytopenia as well as acute radiation esophagitis, mainly Ⅰ ~ Ⅱ degrees. Conclusions The clinical application of 3-D conformal radiotherapy combined with concurrent chemotherapy in patients with advanced esophageal cancer has a good clinical efficacy, and effectively improves the survival rate of patients, despite the toxic side effects, but to a lesser extent, the patients can tolerate the treatment.