目的通过不同剂量的埃索美拉唑与奥美拉唑对胃食管反流病的治疗来评价埃索美拉唑的抑酸作用,同时选择埃索美拉唑的适宜临床使用剂量。方法选择40例经胃镜证实的胃食管反流病患者,分为四组,每组给予不同剂量的药物,在治疗期间测定胃内pH。结果在治疗第5天时,埃索美拉唑40mg组24h胃内平均pH和24h胃内pH>4的百分比均明显高于其他三组,24h胃内pH>4的时间也最长,四组的不良反应事件类型和发生率相似。结论埃索美拉唑40mg的耐受良好,酸抑制能力更强。 Objective To evaluate the inhibitory effect of esomeprazole by different doses of esomeprazole and omeprazole on the treatment of gastroesophageal reflux disease, and to select the appropriate clinical dosage of esomeprazole. Methods Forty patients with gastroesophageal reflux disease confirmed by endoscopy were selected and divided into four groups. Each group was given different doses of drugs, and the intragastric pH was measured during the treatment. Results On the fifth day of treatment, the mean intragastric pH of 24h and the intragastric pH> 4 in 40 mg group of esomeprazole were significantly higher than those in the other three groups, and the intragastric pH> 4 was also the longest in four days The types and rates of adverse events were similar. Conclusion Esomeprazole 40mg is well tolerated and its acid-inhibiting ability is stronger.