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目的观察奥拉西坦治疗脑梗死后认知功能障碍的临床疗效。方法选取2014年1月—2015年6月济宁医学院附属医院收治的脑梗死后认知功能障碍患者195例,随机分为对照组97例和观察组98例。在常规治疗基础上,对照组患者给予奥拉西坦模拟胶囊+吡拉西坦片口服,观察组患者给予奥拉西坦胶囊+吡拉西坦模拟片口服;两组患者均连续治疗6个月。比较两组患者治疗前后蒙特利尔认知评估量表(Mo CA)评分、日常生活能力量表(ADL)评分及简易精神状态检查量表(MMSE)评分差值。结果观察组患者治疗前后Mo CA评分、ADL评分、MMSE评分差值大于对照组(P<0.05)。结论奥拉西坦治疗脑梗死后认知功能障碍的临床疗效确切,可有效改善患者认知功能,提高患者生活质量。
Objective To observe the clinical effect of oxiracetam on cognitive dysfunction after cerebral infarction. Methods 195 patients with cognitive dysfunction after cerebral infarction admitted from January 2014 to June 2015 in Jining Medical College Affiliated Hospital were randomly divided into control group (97 cases) and observation group (98 cases). On the basis of routine treatment, patients in the control group were orally administered with Oxiracetam Simulated Capsule + Piracetam Orally, while patients in the observation group were administered Oxiracetam Capsule + Piracetam Simvastatin orally. In both groups, 6 month. Before and after treatment, the scores of MoCA, ADL and MMSE in both groups were compared. Results The scores of Mo CA, ADL and MMSE before and after treatment in observation group were significantly higher than those in control group (P <0.05). Conclusions Oxiracetam is effective in treating cognitive impairment after cerebral infarction, which can effectively improve the cognitive function and improve the quality of life of patients.