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血小板源生长因子 (PDGF)是一种重要的促细胞分裂剂 ,可以刺激多种细胞分裂和增殖 ,在体内PDGF表达与分泌受白细胞介素 1、缺氧、转化生长因子、血管紧张素II等因素的影响。不同器官的细胞所含PDGF受体的类型有差异性。血小板源生长因子与其受体结合后 ,通过磷酯酰肌醇 3激酶、Ras、磷脂酶激活、Ca2 +离子等途径介导细胞内的信号转导。PDGF在动脉粥样硬化、血管成形术后再狭窄、高血压血管重塑的发生发展中具有重要意义。
Platelet-derived growth factor (PDGF) is an important mitogen that stimulates cell division and proliferation. PDGF expression and secretion are mediated by interleukin-1, hypoxia, transforming growth factor, angiotensin II, etc. The impact of factors. Cells of different organs contain different types of PDGF receptors. After platelet-derived growth factor binds to its receptor, it mediates intracellular signal transduction through phosphatidylinositol 3 kinase, Ras, phospholipase activation, Ca 2+ ion and other pathways. PDGF plays an important role in the development of atherosclerosis, restenosis after angioplasty, and vascular remodeling of hypertension.