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目的研究人端粒酶逆转录酶(hHERT)在胰腺癌组织中的表达及其与临床病理的关系。方法描述胰腺癌的部位、大小、组织分级和临床分明,用SABC免疫组化方法检测hTERT的表达。结果hTERT在胰腺癌组织中表达的阳性率为81.6%,在慢性胰腺炎和正常胰腺组织中表达为0,差异有显著性(P<0.001)。hTERT的表达与肿瘤的部位、大小和组织分级无关(P>0.05),与临床分期有关(P<0.05)。结论hTERT在胰腺癌组织中有较高表达,与临床分期有关。故可以此鉴别胰腺癌和慢性胰腺炎。
Objective To study the expression of human telomerase reverse transcriptase (hHERT) in pancreatic cancer and its relationship with clinicopathology. Methods The location, size, histological grade and clinical manifestations of pancreatic cancer were described. The expression of hTERT was detected by SABC immunohistochemistry. Results The positive expression rate of hTERT in pancreatic cancer tissues was 81.6%, and it was 0 in chronic pancreatitis and normal pancreatic tissues. The difference was significant (P <0.001). The expression of hTERT was not associated with tumor location, size and histological grade (P> 0.05), but was correlated with clinical stage (P <0.05). Conclusion hTERT is highly expressed in pancreatic cancer, which is related to clinical stage. Therefore, this can identify pancreatic cancer and chronic pancreatitis.