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噬血组织细胞增生症(HHH),从临床到病理都易误诊为恶性肿瘤或其它疾病,现报告6例如下:临床资料男性4例、女性2例,最小1.5岁,最大44岁,平均27岁。6例中5例有发热及全身淋巴结肿大,1例为腋窝淋巴结肿大1～2 cm。3例脾肿大1.5～6 cm。2例肝肿大2～4 cm。5例全血细胞减少;RBC160～287万,WBC1250～3500,Plt 2～5万。例2咽拭子培养有霉菌,肛周脓肿为大肠杆菌,例4咽分泌物和大便培养均有绿脓杆菌,例5血培养为白色葡萄球菌,例6 Widal 反应强阳性,例1为弱阳性。例1、3经历2次手术,例1、2输血分别为3200ml、1200ml。临床诊断恶组4例、伤寒1例、乳癌1例。6例中4例死亡、2例
Hemophagocytic hyperplasia (HHH), from clinical to pathological diagnosis of misdiagnosed as malignant tumor or other diseases, are reported in 6 cases as follows: Clinical data of 4 males and 2 females, a minimum of 1.5 years old, maximum 44 years old, an average of 27 year old. In 6 cases, 5 cases had fever and generalized lymphadenopathy, and 1 case had axillary lymph node enlargement of 1 ~ 2 cm. 3 cases splenomegaly 1.5 ~ 6 cm. 2 cases of hepatomegaly 2 ~ 4 cm. 5 cases of pancytopenia; RBC160 ~ 2870000, WBC1250 ~ 3500, Plt2 ~ 50000. Example 2 throat swab mold culture, perianal abscess Escherichia coli, case 4 pharyngeal secretions and stool culture Pseudomonas aeruginosa, blood cultures were Staphylococcus aureus, Example 6 Widal strong reaction, Example 1 is weak Positive. Cases 1 and 3 underwent two surgeries, 1,2 cases of blood transfusion were 3200ml, 1200ml. Clinical diagnosis of evil in 4 cases, 1 case of typhoid fever, 1 case of breast cancer. Of the 6 patients, 4 died and 2 patients died