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本研究发现１０和１００ｎｍｏｌ／Ｌ肾上腺升压素（ａｄｒｅｎｏｔｅｎｓｉｎ，ＡＴ）呈剂量依赖性增加大鼠主动脉环张力（Ｐ＜００１）；２．５ｎｍｏｌ／ｋｇ ＡＴ静脉推注可使麻醉大鼠平均动脉压升高２８％（Ｐ＜０．０１）；１００ｎｍｏｌ／Ｌ可使培养的大鼠血管平滑肌细胞的３Ｈ－胸腺嘧啶核苷参入量增加５５％（Ｐ＜０．０１）；肾上腺髓质素（ａｄｒｅｎｏｍｅｄｕｌｌｉｎ，ＡＭ）则在不同程度上抑制ＡＴ的上述活性；１、１０和１００ｎｍｏｌ／ＬＡＴ可分别抑制ＡＭ的释放率达１９％、３５％和４６％（Ｐ＜０．０５或０．０１），而１０ｎｍｏｌ／ＬＡＭ也是一种新的缩血管、升血压和促进血管平滑肌增殖的多肽；ＡＴ与ＡＭ之间在血管活性上相互拮抗，在释放上交互抑制，这些相互作用可能是肾上腺髓质素原的分子内调节的体现。
This study found that 10 and 100nmol / L adrenotensin (AT) in a dose-dependent manner increased aortic ring tension (P <001); 2.5nmol / kg AT intravenous injection of anesthetized rats can make the average artery (P <0.01); 3H-thymidine incorporation increased by 55% (P <0.01) in 100 nmol / L rat vascular smooth muscle cells; Adrenomedullin adrenomedullin, AM) inhibited the above-mentioned activities of AT to varying degrees; 1, 10 and 100nmol / LAT could inhibit the release rate of AM to 19%, 35% and 46% (P <0.05 or 0.01) However, 10 nmol / LAM is also a novel polypeptide that vasoconstricturizes, increases blood pressure and promotes the proliferation of vascular smooth muscle. AT and AM are antagonistic to each other in vasoactivity and are mutually inhibited in release. These interactions may be adrenomedullin of Embodied within the sub-regulated.