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目的:探讨非小细胞肺癌NSCLC胸内淋巴结转移的特点和范围及其对合理的放疗布野的意义。方法:1996年1~12月,175例NSCLC行肺叶或全肺切除加同侧纵隔淋巴结清扫,对切除的707个淋巴结进行病理分析。结果:NSCLC胸内淋巴结转移首先至肺内组、肺门组,然后至纵隔各区,纵隔各区淋巴结转移与原发肿瘤部位有关。术后1年内上叶肺癌所致上纵隔淋巴结转移的患者中77.4%24/31出现锁骨上淋巴结肿大。中叶肺癌上纵隔与隆突下淋巴结转移机率大致相等。下叶肺癌上纵隔淋巴结转移少见。鳞癌以1组N2转移为主,占75%。腺癌和腺鳞癌则以≥2组N2为主,分别为63.6%和54.5%P< 0.005P< 0.05。临床N分期和病理N分期差异较大。结论:准确的病理学N分期,有助于指导NSCLC的放射治疗设野。
Objective: To investigate the characteristics and scope of thymus lymph node metastasis in non-small cell lung cancer (NSCLC) and its significance to reasonable radiotherapy field. Methods: From January to December 1996, 175 cases of NSCLC underwent lobectomy or pneumonectomy combined with ipsilateral mediastinal lymph node dissection. Pathological analysis was performed on 707 resected lymph nodes. Results: Thoracic lymph node metastasis of NSCLC first to pulmonary group, hilar group, and then to the mediastinum, mediastinal lymph node metastasis and the primary tumor site. One year after operation, 77.4% of the patients with mediastinal lymph node metastasis due to upper lobe lung cancer had an enlarged supraclavicular lymph node. The median lung cancer and mediastinum lymph node metastasis probability roughly equal. Lower lobes on the mediastinal lymph node metastasis rare. Squamous cell carcinoma with a group of N2-based transfer, accounting for 75%. Adenocarcinoma and adenosquamous carcinoma with ≥ 2 groups of N2-based, respectively, 63.6% and 54.5% P <0.005 P <0.05 . Clinical N staging and pathological N staging differences. Conclusion: Accurate pathological N staging helps to guide the radiation therapy of NSCLC.