论文部分内容阅读
目的探讨HIV感染者/AIDS患者(HIV/AIDS)近期预后的危险因素。方法回顾性分析164例HIV/AIDS患者的基线(性别、年龄、婚姻状况、传播途径、WHO临床分期和CD4+T淋巴细胞)及随访资料(是否开始HAART、预后状态和生存时间),观察期为48周,用Kaplan-Meier法计算平均生存期,生存函数曲线的比较用Log Rank检验。结果 164例HIV/AIDS患者在随访期内生存105例(64.02%),死亡59例(35.98%),其中24周内累计死亡55例(93.22%),死亡原因均为AIDS相关性疾病。本研究中年龄≤50岁组的平均生存期(269d)高于年龄>50岁组(209d)(P<0.05);男性组的平均生存期(226d)小于女性组(303d)(P<0.05);WHO临床分期I,II和III期组的平均生存期(330d)明显高于WHO临床分期Ⅳ期组(172d)(P<0.05);基线CD4+>50个/mm3组的平均生存期(297d)也高于基线CD4+≤50个/mm3组(205d)(P<0.05);未开始HAART组平均生存期只有48d,明显低于已接受HAART组(336d)(P<0.05);性传播者的平均生存期(253d)和血液传播者(274d)相近(P>0.05)。结论确诊HIV/AIDS时的年龄>50岁、男性、WHO临床IV期、基线CD4+≤50个/mm3和未开始HAART是影响本地区HIV/AIDS患者近期预后的危险因素。
Objective To explore the risk factors for the recent prognosis of HIV / AIDS patients (HIV / AIDS). Methods The baseline (gender, age, marital status, route of transmission, WHO clinical stage and CD4 + T lymphocyte) and follow-up data (whether or not to start HAART, prognosis and survival time) of 164 HIV / AIDS patients were retrospectively analyzed. For 48 weeks, the mean survival time was calculated using the Kaplan-Meier method, and the survival function curves were compared using the Log Rank test. Results A total of 164 HIV / AIDS patients survived in 105 cases (64.02%) and 59 (35.98%) died during the follow-up period. Among them, 55 (93.22%) died in 24 weeks and all the causes of death were AIDS-related diseases. In our study, the mean survival time (269 days) was lower than that of the age group> 50 years (209 days) (P <0.05). The mean survival time of the male group (226 days) was less than that of the female group (303 days) ). The mean survival time of the WHO clinical stage I, II and III group (330d) was significantly higher than that of the WHO clinical stage IV group (172d) (P <0.05). The mean survival time of the baseline CD4 +> 50 / (P <0.05). The mean survival time of the untreated HAART group was only 48 days, which was significantly lower than that of the HAART group (336 days) (P <0.05). Sexual transmission The average survival time (253d) and blood-borne (274d) were similar (P> 0.05). Conclusions Age> 50 years of diagnosis of HIV / AIDS, male, WHO stage IV, baseline CD4 + ≤50 / mm3 and not started HAART are risk factors for the near future prognosis of HIV / AIDS patients in this area.