目的研究分析医源性早产相关因素和围生儿结局。方法抽取2012年1月—2014年12月在郑州大学第三附属医院住院分娩的医源性早产患者2 108例。对医源性早产孕妇的临床资料进行分析研究,对医源性早产儿分组研究其围生儿结局。结果 2012年1月—2014年12月在郑州大学第三附属医院住院分娩的早产患者共4 976例,其中医源性早产孕妇2 108例,占早产的42.38%。导致医源性早产的相关危险因素依次为妊娠期高血压疾病,前置胎盘,羊水因素等;随着胎龄和出生体重的增加,早产儿的并发症发生率、妊娠结局均显著改善,各组之间的差异显著(P<0.05)。结论妊娠期高血压疾病、前置胎盘、羊水因素等为医源性早产的主要危险因素,且多数为多因素共同存在,坚持孕期定期产检,及时发现疾病并治疗,积极避免并降低医源性早产的发生;在医源性早产的治疗中应尽量延长孕周,以降低新生儿近远期并发症发生率和死亡率。 Objective To analyze and analyze the related factors of iatrogenic preterm birth and perinatal outcome. Methods A total of 2 108 cases of iatrogenic preterm labor were collected from January 2012 to December 2014 in the Third Affiliated Hospital of Zhengzhou University. The clinical data of pregnant women with iatrogenic premature birth were analyzed and studied, and their perinatal outcome was studied in groups of iatrogenic preterm children. Results A total of 4 976 preterm delivery patients were hospitalized at the Third Affiliated Hospital of Zhengzhou University from January 2012 to December 2014. Among them, 2 108 pregnant women with preterm birth were iatrogenic, accounting for 42.38% of preterm birth. The related risk factors leading to iatrogenic preterm birth were as follows: gestational hypertension, placenta previa, amniotic fluid factors, etc .; with the increase of gestational age and birth weight, the incidence of complications and pregnancy outcomes in preterm infants were significantly improved. Differences between groups were significant (P <0.05). Conclusions Pregnancy-induced hypertension, placenta previa and amniotic fluid factors are the main risk factors of iatrogenic preterm birth. Most of them are multifactorial co-existing. They insist on regular antenatal check-up during pregnancy, find out the disease and treat in time, and actively avoid and reduce iatrogenic Premature birth occurs; in the treatment of iatrogenic preterm labor should be prolonged gestational age, in order to reduce the incidence of neonatal complications and short-term mortality.