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目的:探讨年轻乳腺癌患者的临床病理特点及影响其预后的相关因素。方法:选取潍坊市人民医院2005年11月至2011年11月收治的年龄不高于35岁的137例年轻乳腺癌患者的临床资料,其中共有116例入组,初步分析年轻乳腺癌患者的临床病理特征及对预后产生的影响。结果:116例患者中位随访时间为46.0个月。3年OS和PFS为94.6%和79.1%。单因素、多因素分析结果显示淋巴结转移情况和Ki67水平与预后的显著相关(P<0.05),淋巴结转数目、Ki67水平与预后呈负相关。结论:年轻乳腺癌患者的生物学行为、病理及预后较为特殊。淋巴结转移情况、Ki67水平是影响预后的关键因素。
Objective: To investigate the clinicopathological features of young breast cancer patients and the related factors that affect their prognosis. Methods: The clinical data of 137 young breast cancer patients who were under 35 years of age from November 2005 to November 2011 in Weifang People’s Hospital were selected. A total of 116 patients were enrolled in this study. The clinical data of young breast cancer patients Pathological features and prognosis. Results: The median follow-up time of 116 patients was 46.0 months. The 3-year OS and PFS were 94.6% and 79.1%. Univariate and multivariate analysis showed that there was a significant correlation between lymph node metastasis and Ki67 level and prognosis (P <0.05). The number of lymph node metastasis and Ki67 level were negatively correlated with prognosis. Conclusion: The biological behavior, pathology and prognosis of young breast cancer patients are rather special. Lymph node metastasis, Ki67 level is the key factor affecting the prognosis.