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膀胱癌是常见的泌尿系统肿瘤,具有易复发和产生多药耐药的生物学特性。肿瘤细胞的药物耐受是影响化疗效果的最重要因素。多药转运蛋白最突出的作用是它可以从癌细胞中向外转运抗癌药物,使机体产生耐药。而大量研究表明,它们在肿瘤生物学中的基本作用要比对药物的转运更为重要。明确这些转运蛋白在肿瘤发生及治疗反应中的具体作用对膀胱癌的靶向治疗至关重要。
Bladder cancer is a common urological tumor that has the biological characteristics of being easy to relapse and producing multi-drug resistance. Drug resistance of tumor cells is the most important factor that affects the effect of chemotherapy. The most prominent role of multi-drug transporter is that it can transfer anticancer drugs out of cancer cells and make the body produce drug resistance. A large number of studies show that their basic role in tumor biology is more important than the drug transport. A clear understanding of the specific role of these transporters in tumorigenesis and therapeutic response is crucial for targeted therapy of bladder cancer.