【摘 要】
：
Aggregation-induced emission luminogens(AIEgens)have been used in biomacromolecules detection.Herein,TPE-dC and TPE-dU acted as the nucleoside-based AIEgens sen
【机 构】
：
Institute for Advanced Study,Shenzhen University,Shenzhen 518060,China;Key Laboratory of Optoelectro
论文部分内容阅读
Aggregation-induced emission luminogens(AIEgens)have been used in biomacromolecules detection.Herein,TPE-dC and TPE-dU acted as the nucleoside-based AIEgens sensors in the first case,which can be used to detect ctDNA and rRNA in vitro and light up the nucleus in vivo depending on the intermolecular binding affinity.This AlE process enables the quantitative analysis or visualization of nucleic acids in solution or gels state,respectively.Furthermore,confocal laser scanning microscopy(CLSM)images of L929 cells stained with TPE-dC or TPE-dU clearly shows that nucleoside-based AIEgens bio-probes can pass the cell membranes to reach the cell nucleus,without cytotoxicity at the imaging condition(incubation time＞12 h,and 10μmol/L of concentration).Since the nucleus is rich in DNA/RNA,fluorescence turn-on mode has a great potential in nucleus imaging and clinical diagnosis.
其他文献
The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein phosphatase non-receptor type 11(PTPN11
Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted i
Fragrances are frequently added to a variety of products,including food,cosmetics and health products.However,the high volatility and instability of essence limit its application in some fields.In this study,mesoporous silica nanoparticles(MSNs) were prep
当今的企业一般不会缺少管理,而是缺少战略管理.许多企业人终日辛劳,忙得焦头烂额,却是在用战术上的勤奋掩盖战略上的懒惰,整天忙的都是一些事务性工作,哪里会有什么战略可言
An efficient approach to sulfur-bridged imidazopyridines has been developed under metal-free conditions using inexpensive sulfur powder as the sulfur source.Most appealingly,the reaction can proceed smoothly without addition of any additives,ultimately de
井冈山是江西省吉安市所属的一个县级市.吉安是一个红遍的地方,有13个县市区留下了毛泽东的足迹,中国革命许多重大事件和重大转折都发生在吉安.1957年,成立了井冈山垦殖场,19
A Zn-containing graphite carbon(Zn-GC)with uniform Zn metal sites and hierarchical pore structure was obtained by pyrolysis of Zn-based metal organic framework(
Since the discovery of left-handed G-quadruplex(L-G4)structure formed by natural DNA,there has been a growing interest in its potential functions.This study uti