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研究培哚普利对25例原发性高血压左室肥厚（LVH）的逆转效应及心功能的影响。疗程8周,剂量4～8mg,每日1次口服。结果显示,培哚普利降压疗效显著,LVH的逆转效应在短期（4周）治疗即可出现,8周后更为明显,左室重量指数（LV-MI）从143.2±21.3降至126.6±15.3g/m~2（P<0.001）,LV-MI降低主要由于空间隔及左室后壁厚度的减小所致,左室舒张末期内径无变化。左室收缩功能无变化,舒张功能（E/A）显著改善,E/A的增加百分率与LVMI的降低百分率呈正相关。研究表明,培哚普利每日1次口服短期可引起LVH的逆转伴有左室舒张功能的改善。
To investigate the effect of perindopril on reversal effect and cardiac function in 25 patients with essential hypertension with left ventricular hypertrophy (LVH). Treatment for 8 weeks, the dose of 4 ~ 8mg, 1 day orally. The results showed that perindopril had a significant antihypertensive effect, and the reversal effect of LVH could be observed after a short-term (4 weeks) treatment. After 8 weeks, the LV-MI decreased from 143.2 ± 21.3 to 126.6 ± 15.3g / m ~ 2 (P <0.001). The decrease of LV-MI was mainly attributed to the reduction of the space septum and the thickness of the posterior wall of the left ventricle, and no change of the diastolic diameter of the left ventricle. No change in left ventricular systolic function, diastolic function (E / A) was significantly improved, the percentage increase of E / A and LVMI was positively correlated. Studies have shown that perindopril once daily oral short-term can cause reversal of LVH accompanied by improvement of left ventricular diastolic function.