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目的观察酚妥拉明微量泵维持治疗新生儿坏死性小肠结肠炎(NEC)的临床效果。方法 NECⅠ期、Ⅱ期患儿45例随机分为二组,治疗组23例在常规治疗基础上使用酚妥拉明1.7~3.3μg/(kg.min)微量泵泵入;对照组22例常规治疗,比较二组总有效率及不良反应,有效患儿腹胀消失、恢复肠内营养及治愈时间。结果治疗组总有效率95.6%,对照组68.2%,差异有统计学意义(χ2=4.08,P<0.05);治疗组有效患儿腹胀消失、恢复肠内营养及治愈时间均短于对照组,差异有统计学意义,无不良反应。结论酚妥拉明泵维治疗NEC疗效显著,无不良反应。
Objective To observe the clinical effect of phentolamine micropump in maintenance of neonatal necrotizing enterocolitis (NEC). Methods Forty-five children with stage NECⅠ and Ⅱ were randomly divided into two groups. The treatment group received phentolamine (1.7-3.3μg / (kg · min)) on the basis of routine treatment and the control group (n = 22) Treatment, the two groups were compared the total efficiency and adverse reactions, effective disappearance of children with abdominal distension, recovery of enteral nutrition and healing time. Results The total effective rate was 95.6% in the treatment group and 68.2% in the control group, the difference was statistically significant (χ2 = 4.08, P <0.05). The effective children in the treatment group disappeared and the enteral nutrition and healing time were shorter than the control group, The difference was statistically significant, no adverse reactions. Conclusion Phentolamine pump treatment of NEC significant effect, no adverse reactions.