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目的 :探讨G CSF及TNFα在慢性阻塞性肺疾病 (COPD)发病中的作用和临床意义。方法 :应用ELISA法测定 43例COPD急性期患者和 39例COPD稳定期患者血清G CSF和TNFα水平 ,并同健康正常人对照。结果 :COPD急性加重期患者血清G CSF和TNFα水平显著高于健康对照组及稳定期患者 (P <0 0 5 ) ,血清G CSF水平分别与TNFα含量及中性粒细胞计数呈正相关 (r值分别为 0 6 3和 0 74,P值均小于 0 0 5 )。结论 :G CSF和TNFα参与COPD发病 ,监测血清G CSF和TNFα有助于对患者病情判断及疗效观察。
Objective: To investigate the role and clinical significance of G CSF and TNFα in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods: Serum levels of G-CSF and TNF-α in 43 patients with acute COPD and 39 patients with stable COPD were determined by ELISA and compared with healthy controls. Results: Serum levels of G CSF and TNFα in patients with acute exacerbation of COPD were significantly higher than those in healthy controls and stable patients (P <0.05). Serum G CSF levels were positively correlated with TNFα levels and neutrophil count (r Respectively 0 6 3 and 0 74, with P values less than 0 0 5). Conclusion: G CSF and TNFα are involved in the pathogenesis of COPD. Monitoring serum G CSF and TNFα may be helpful to judge the patient’s condition and observe the curative effect.