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目的:观察1,6-二磷酸果糖联合纳络酮治疗新生儿缺氧缺血性心肌损害的疗效。方法:在常规治疗基础上30例加用1,6-二磷酸果糖和纳络酮治疗5天,并与对照组32例(常规治疗)比较。结果:治疗组总有效率为96.7%,对照组总有效率71.9%,两组有显著性差异(χ2=5.32,P<0.05)。结论:1,6-二磷酸果糖联合纳络酮治疗新生儿缺氧缺血性心肌损害疗效显著,未见毒副作用及不良反应发生,值得进一步研究和推广。
Objective: To observe the therapeutic effect of fructose-1,6-diphosphate combined with naloxone on neonatal hypoxic-ischemic myocardial damage. Methods: On the basis of conventional treatment, 30 cases were treated with fructose-1,6-diphosphate and naloxone for 5 days, and compared with the control group of 32 cases (routine treatment). Results: The total effective rate was 96.7% in the treatment group and 71.9% in the control group, with significant difference between the two groups (χ2 = 5.32, P <0.05). CONCLUSION: Fructose-1,6-diphosphate combined with naloxone is effective in treating neonatal hypoxic-ischemic myocardial damage. No side effects and adverse reactions occurred. It deserves further study and promotion.