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目的探讨炎症因子、凝血功能在进展性脑梗死患者中的检测意义。方法 100例脑梗死患者,其中39例进展性脑梗死患者作为进展性脑梗死组,其余61例非进展性脑梗死患者作为脑梗死组,选择同期健康体检者50例作为对照组。检测三组凝血指标、炎症因子(淀粉样蛋白A、超敏C反应蛋白)水平。结果脑梗死组和进展性脑梗死组的凝血酶原时间、部分凝血活酶时间、凝血酶时间均低于对照组,差异均有统计学意义(P<0.05);进展性脑梗死组的凝血酶原时间、部分凝血活酶时间、凝血酶时间均低于脑梗死组,差异均有统计学意义(P<0.05);脑梗死组和进展性脑梗死组超敏C反应蛋白、纤维蛋白原和淀粉样蛋白A含量均高于对照组,差异均有统计学意义(P<0.05);进展性脑梗死组超敏C反应蛋白、纤维蛋白原和淀粉样蛋白A含量高于脑梗死组,差异均有统计学意义(P<0.05)。结论炎症因子、凝血功能检测有助于了解脑梗死病情进展情况,有助于脑梗死患者病情进展监测。
Objective To investigate the significance of inflammatory factors and coagulation in patients with progressive cerebral infarction. Methods 100 patients with cerebral infarction, including 39 patients with progressive cerebral infarction as a progressive cerebral infarction group, the remaining 61 patients with non-progressive cerebral infarction as cerebral infarction group, the same period selected 50 healthy subjects as a control group. Three groups of coagulation indexes, inflammatory factors (amyloid A, hypersensitive C-reactive protein) were detected. Results The prothrombin time, partial thromboplastin time, and thrombin time in cerebral infarction group and progressive cerebral infarction group were all lower than those in control group (P <0.05). The levels of blood coagulation The time of prothrombin time, partial thromboplastin time and thrombin time were all lower than that of cerebral infarction group (P <0.05). The levels of hypersensitive C-reactive protein and fibrinogen in cerebral infarction group and progressive cerebral infarction group And amyloid A were higher than those in the control group (P <0.05). The content of Hs-CRP, fibrinogen and amyloid A in cerebral infarction group were higher than those in cerebral infarction group, The differences were statistically significant (P <0.05). Conclusion Inflammatory factors and coagulation tests may help to understand the progress of cerebral infarction and help to monitor the progression of cerebral infarction.