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目的 分析儿童急性白血病(AL)的免疫表型特点。方法 采用单克隆抗体(McAb)和流式细胞仪(FCM)对35例儿童AL进行免疫分型。结果 T系ALL占31 .0%,B系ALL占69 .0%,其中髓系抗原表达率17 .2%;T-ALL中CD3 阳性率较CD2、CD7 低,B-ALL中CD22阳性率低于CD10、CD19。CD34阳性表达率在B-ALL中为40. 0%。CD34阳性的完全缓解(CR)率明显低于阴性组。结论 免疫表型的研究将有助于指导临床治疗及判断预后。
Objective To analyze the immunophenotypic characteristics of childhood acute leukemia (AL). Methods Immunohistochemistry was performed on 35 children with monoclonal antibody (McAb) and flow cytometry (FCM). Results T-ALL accounted for 31.0%, while B-ALL accounted for 69.0%. The myeloid antigen expression rate was 17.2%. The positive rate of CD3 in T-ALL was lower than that in CD2 and CD7, and the positive rate of CD22 in B-ALL Lower than CD10, CD19. The positive expression rate of CD34 in B-ALL was 40.0%. The complete remission (CR) rate of CD34 positive was significantly lower than that of the negative group. Conclusion The study of immunophenotype will help to guide the clinical treatment and prognosis.