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目的初步探讨男性染色体平衡易位携带者行常规IVF或ICSI技术治疗后的临床妊娠结局,为此类患者的辅助生育治疗及遗传咨询提供指导。方法比较研究36例男方携带染色体平衡易位的不育症夫妇(观察组)及751例染色体正常的不育症夫妇(对照组)在行常规IVF或ICSI治疗后的临床妊娠率、胚胎着床率、多胎妊娠率、活胎分娩率、流产率等指标。结果 36例男方染色体平衡易位的不育症夫妇,共进行38次取卵,完成38个新鲜胚胎移植治疗周期和13个冷冻胚胎移植治疗周期,其中有24个周期获得临床妊娠,5个周期早期自然流产,总计18对夫妇成功分娩了24个婴儿,每取卵周期活胎分娩率达47.4%(18/38)。随访未见晚期流产、死胎、畸胎或出生畸形儿的病例。观察组与对照组间临床妊娠率、胚胎着床率、多胎妊娠率、活胎分娩率、流产率均无显著性差异(P>0.05)。结论对于男方携带染色体平衡易位的不孕不育患者,除PGD外,常规的IVF或ICSI也是一种可供考虑的选择,这类患者行常规IVF或ICSI可获得与非携带者相似的妊娠结局。
Objective To investigate the clinical pregnancy outcome after routine IVF or ICSI treatment of male chromosome-balance-translocated carriers and to provide guidance for such patients in assisted reproductive therapy and genetic counseling. Methods A total of 36 male infertile couples with chromosomal equilibrium translocations (observation group) and 751 normal infertile couples (control group) underwent routine IVF or ICSI treatment were compared in terms of clinical pregnancy rate, embryo implantation Rate, multiple pregnancy rate, live birth rate, abortion rate and other indicators. RESULTS: Thirty-six male infertile couples with balanced chromosomal translocation had 38 cycles of ovulation, 38 cycles of fresh embryo transfer and 13 cycles of frozen embryo transfer, of which 24 cycles achieved clinical pregnancy and 5 cycles Early spontaneous abortion, a total of 18 couples delivered 24 babies successfully, with a live birth rate of 47.4% (18/38) per ovulation cycle. No cases of late miscarriage, stillbirth, teratology or birth deformity were observed. Clinical pregnancy rate, embryo implantation rate, multiple pregnancy rate, live birth rate and abortion rate had no significant difference between observation group and control group (P> 0.05). CONCLUSIONS: In addition to PGD, routine IVF or ICSI is also considered as an option for men with infertile patients with chromosomal equilibrium translocations, and such patients may receive gestationally similar pregnancies with routine IVF or ICSI ending.