1例74岁男性患者,因直肠癌根治术后出现咳嗽、咯痰、发热约1个月,先后给予拉氧头孢钠、比阿培南、莫西沙星、替考拉宁、盐酸万古霉素、利柰唑胺和达托霉素治疗.在应用替考拉宁12d后换用莫西沙星,应用莫西沙星的第4天,患者四肢及躯干部位出现充血性皮疹伴瘙痒感.停用莫西沙星、改用盐酸万古霉素并给予抗过敏对症治疗后患者皮疹好转.应用盐酸万古霉素第8天,患者四肢再次出现红疹,停用盐酸万古霉素并换用替考拉宁.应用替考拉宁第5天患者皮疹加重,部分皮疹表面出现水泡并连接成片,换用利奈唑胺并继续抗过敏治疗,陈旧水泡逐渐吸收,未再出现新发水疱.考虑可能为替考拉宁引起的迟发型过敏反应,不排除还存在与盐酸万古霉素交叉过敏的可能.“,”A 74-year-old male patient received latamoxef,biapenem,moxifloxacin,teicoplanin,vancomycin hydrochloride,linezolid,and daptomycin in succession for about one month of cough,expectoration,and fever after resection of rectal cancer.Teicoplanin was changed to moxifloxacin after 12 days of teicoplanin treatment.On day 4 of moxifloxacin treatment,the patient developed congestive rash and itching on his limbs and trunk.Moxifloxacin was stopped and changed to vancomycin hydrochloride as well as anti-allergic treatment,and then the rash improved.On day 8 of vancomycin hydrochloride treatment,the patient developed rash again on his limbs.Vancomycin hydrochloride was withdrawn and changed to teicoplanin.On day 5 of teicoplanin treatment,more rash occurred and some of them developed vesicles on the surface and fused into lamella.Linezolid was given and anti-allergic treatment was continued.Old vesicles were absorbed gradually and no new vesicles reoccurred.Teicoplanin-induced delayed-type hypersensitivity was considered.Cross allergies caused by vancomycin hydrochloride and teicoplanin could not be excluded.