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应用透射电子显微镜观察猪脊髓前角匀浆免疫后豚鼠脊髓前角运动神经元的超微结构改变,并进一步探讨其发病机制。结果显示:免疫后豚鼠脊髓前角运动神经元可见内质网扩张、线粒体肿胀;胞浆基质及细胞器致密化;有髓神经纤维内神经丝局部积聚、大量线粒体及溶酶体聚集;前根及坐骨神经大的有髓神经纤维轴索萎缩,髓鞘结构保存相对较好。以上结果提示自身免疫机制能诱导脊髓前角运动神经元的损伤,轴浆转运异常可能参与其致病过程。
Transmission electron microscopy was used to observe ultrastructural changes of motor neurons in guinea pig spinal cord anterior horn after immunization with porcine spinal cord anterior horn, and to further explore its pathogenesis. The results showed that: after immunization, the anterior horn motor neurons of the spinal cord showed dilated endoplasmic reticulum, swelling of mitochondria, densification of cytoplasm and organelles, local accumulation of neurofilaments in the myelinated nerve fibers, accumulation of a large number of mitochondria and lysosomes, Sciatic nerve axon large atrophy, preservation of myelin structure is relatively good. These results suggest that autoimmune mechanism can induce spinal cord anterior horn motor neuron injury, abnormal axonal transport may be involved in the pathogenesis.