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人类的基因治疗于 2 0世纪 80年代初期被提出并实施 ,当时的研究对象主要是单基因遗传病。 1990年 11月 ,美国国立癌症研究所 (national cancerinstitute,NCI)的 Posenberg研究小组获准用 TNF基因转染的肿瘤浸润淋巴细胞 (TIL )治疗晚期黑色素瘤患者 ,开创了人类恶性肿瘤基因治
Human gene therapy was proposed and implemented in the early 1980s when the study focused primarily on single-gene disorders. In November 1990, the Posenberg research team of the National Cancer Institute (NCI) approved treatment of patients with advanced melanoma with tumor-infiltrating lymphocytes (TILs) transfected with the TNF gene and pioneered gene therapy of human malignancies