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检测９２例反复呼吸道感染（ＲＲＴＩ）和４２例健康儿童血清ＩｇＧ亚类、外周血Ｔ细胞及其亚群。结果表明，ＲＲＴＩ组ＩｇＧ亚类缺陷检出率为４５．２３％（３８／８４），以选择性缺陷为主，ＩｇＧ缺陷居多（３３．３３％）；ＲＲＴＩ患儿血清ｌｇＧ_２均值在各年龄组中均明显低于对照组；ＲＲＴＩ组ｃｄ_３~＋细胞、ＣＤ_４~＋方细胞、ＣＤ_８~＋细胞百分率和ＣＤ_４~＋／ＣＤ_８~＋细胞比值亦均显著低于对照组。提示ＩｇＧ亚类缺陷，尤其是ＩｇＧ_２缺陷是ＲＲＴＩ发病的重要机理，外周血Ｔ细胞功能及亚群的异常与ＩｇＧ亚类缺陷可能有密切关系。
92 cases of recurrent respiratory tract infection (RRTI) and 42 healthy children serum IgG subclasses, peripheral blood T cells and their subgroups. The results showed that the detection rate of IgG subclass defects in RRTI group was 45.23% (38/84), with the majority of selective defects and the majority of IgG deficiency (33.33%). The mean serum lgG_2 in RRTI group was significantly higher in all age groups Were significantly lower than those in the control group. The percentages of CD_3 ~ + cells, CD_4 ~ + cells, CD_8 ~ + cells and CD_4 ~ + / CD_8 ~ + cells in RRTI group were also significantly lower than those in the control group. It is suggested that IgG subclass deficiency, especially IgG2 deficiency, is an important mechanism of RRTI. Peripheral blood T cell function and subgroup abnormalities may be closely related to IgG subclass defects.