论文部分内容阅读
N—甲基—N′—硝基—N—亚硝基胍(N—methyl—N′—Nitro—N—Nitrosoquanidine.简称MNNG)是一种强烈的致突变物和致癌物,1967年,日本学者Sugimura和Fujimura用MNNG水溶液连续给大白鼠自由饮用成功地诱发了大白鼠腺胃胃癌,为胃癌的实验性研究提供了简便有效,(1.2)诱癌率高,且更接近自然饲养的方法。79年,我们用自制MNNG进行了复制大白鼠腺胃胃癌模型的实验,诱发了一定比例数的腺胃胃癌。兹将实验结果以及诱发大白鼠胃癌的病理形态学变化总结报告如下:
N-Methyl-N’-Nitro-N-Nitrosoquanidine (MNNG) is a strong mutagen and carcinogen. In 1967, Japan Scholars Sugimura and Fujimura succeeded in inducing gastric adenocarcinoma of the stomach in mice with MNNG in aqueous solution, which provided a simple and effective method for the experimental study of gastric cancer, and (1.2) had a high induction rate and was closer to natural breeding. In 79 years, we used a homemade MNNG to perform experiments on replicating gastric adenocarcinoma in rat models, and induced a certain percentage of glandular stomach cancer. The summary report of the experimental results and pathological changes induced by rat stomach cancer is as follows: