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目的:观察清肺散结汤配合化疗对晚期非小细胞肺癌患者临床疗效及生活质量的影响。方法:将60例患者随机分为对照组30例和治疗组30例。两组均采用TP方案化疗;治疗组在化疗前2 d加用清肺散结汤治疗。两组患者均21 d为1个周期,2个周期评价疗效。观察两组近期疗效,治疗前后中医临床证候变化、生活质量积分、KPS评分及不良反应变化情况。结果:两组近期疗效比较,治疗组与对照组总有效率分别为36.7%和30%,经统计学处理,无显著性差异(P>0.05)。两组中医临床证候变化比较,治疗组与对照组总改善率分别为86.7%和66.7%,两组间比较,差异有统计学意义(P<0.05);两组生活质量与KPS评分治疗前后比较,治疗组明显优于对照组,差异有统计学意义(P<0.05);两组不良反应比较,治疗组低于对照组,差异有统计学意义(P<0.05)。结果:清肺散结汤配合化疗治疗晚期非小细胞肺癌能提高患者机体免疫功能,改善临床症状,减轻不良反应,提高生活质量,延长生存期。
Objective: To observe the effect of Qingfei Sanjie Decoction combined with chemotherapy on the clinical efficacy and quality of life in patients with advanced non-small cell lung cancer. Methods: 60 patients were randomly divided into control group 30 cases and treatment group 30 cases. TP regimen chemotherapy was used in both groups; treatment group was treated with Qingfei Sanjie Decoction 2 days before chemotherapy. Two groups of patients were 21 days for a cycle, 2 cycles evaluation of efficacy. The two groups were observed the short-term curative effect, the changes of clinical syndromes, quality of life scores, KPS scores and adverse reactions before and after treatment. Results: The two groups of recent efficacy, the treatment group and the control group, the total effective rate was 36.7% and 30%, respectively, statistically no significant difference (P> 0.05). The clinical syndromes of the two groups were compared. The total improvement rates of the treatment group and the control group were 86.7% and 66.7%, respectively. There was significant difference between the two groups (P <0.05). The quality of life and KPS score before and after treatment (P <0.05). Compared with the control group, the treatment group was significantly better than the control group (P <0.05). Compared with the control group, the treatment group was lower than the control group, the difference was statistically significant (P <0.05). Results: Qingfei Sanjie Decoction combined with chemotherapy for advanced non-small cell lung cancer can improve immune function, improve clinical symptoms, reduce adverse reactions, improve quality of life and prolong survival.