【摘 要】
:
A 2D discrete mathematical model of a nine-point finite difference scheme is built to simulate tumor-induced angiogenesis. Nine motion directions of an individu
【机 构】
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School of Medical Instrument and Food Engineering,School of Energy and Power Engineering,Department
【基金项目】
:
Science Foundation for the Excellent Youth Scholars of Higher Education of Shanghai;Research Fund for the Doctoral Program of University of Shanghai for Science and Technology;国家自然科学基金
论文部分内容阅读
A 2D discrete mathematical model of a nine-point finite difference scheme is built to simulate tumor-induced angiogenesis. Nine motion directions of an individual endothelial cell and two parent vessels are extended in the present model. The process of tumor-induced angiogenesis is performed by coupling random motility, chemotaxis, and haptotaxis of endothelial cell in different mechanical environments inside and outside the tumor. The results show that nearly realistic tumor microvascular networks with neoplastic pathophysiological characteristics can be generated from the present model. Moreover, the theoretical capillary networks generated in numerical simulations of the discrete model may provide useful information for further clinical research.
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