论文部分内容阅读
作者从低LET对淋巴细胞质膜生物效应的角度出发,用ERFC、ERFC、M_ERFC、FI-TC-SPA、FITC-IgG电镜观察、膜表面帽状反应、ConA诱导的淋巴细胞凝集反应等指标,并结合松胞素B或秋水仙素对比实验,研究了经不同低剂量~(60)Coγ射线照射后,人淋巴细胞质膜的各种受体的功能变化。结果表明,电离辐射除直接引起淋巴细胞质膜的识别功能和结构改变外,还可能与微丝、微管功能受损有关。另外,对恶性肿瘤病人及其放疗后的免疫功能状态进行了测定。还观察了超氧化物歧化酶(SOD)对小鼠脾脏细胞体外集落(CFUC)的形成具有抗辐射作用。这些研究为辐射免疫学提供了一些实验资料。
From the perspective of low LET on the biological effects of plasma membrane of lymphocytes, the authors used ERFC, ERFC, M_ERFC, FI-TC-SPA, FITC-IgG electron microscope observation, membrane surface cap reaction, ConA-induced lymphocyte agglutination and other indicators, and In combination with cytosine B or colchicine contrast experiments, the functional changes of various receptors in the plasma membrane of human lymphocytes after irradiation with different doses of 60 Co γ-rays were studied. The results showed that ionizing radiation may be related to the impaired function of microfilaments and microtubules in addition to the direct recognition and structural changes of the plasma membrane of lymphocytes. In addition, patients with malignant tumors and their immune function after radiotherapy were measured. Superoxide dismutase (SOD) was also observed to have anti-radiation effects on the formation of mouse splenocytes in vitro colony (CFUC). These studies provide some experimental data for radiation immunology.