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目的观察链蛋白p120(p120ctn)、血管内皮生长因子(VEGF)在膀胱尿路上皮癌组织中的表达变化,并探讨其意义。方法采用免疫组化(S-P)法检测100例膀胱尿路上皮癌(膀胱癌组)及40例正常膀胱黏膜(正常组)中的p120ctn、VEGF蛋白表达情况,并分析两者间及蛋白表达与膀胱尿路上皮癌临床分期、病理分级的关系。结果膀胱癌组和正常组p120ctn阳性表达率分别为54%和87.5%,差异有统计学意义(P<0.05);VEGF阳性表达率分别为93%和42.5%,差异有统计学意义(P<0.05)。在膀胱癌组织中p120ctn和VEGF蛋白的表达水平和肿瘤的病理分型、临床分期呈正相关趋势。结论 p120ctn和VEGF的表达水平在膀胱癌的发生发展过程中发生变化并与肿瘤的病理分级和临床分期相关,可作为判断膀胱癌生物学特征的重要指标。
Objective To observe the expression changes of p120ctn and VEGF in bladder urothelial carcinoma and to explore its significance. Methods The expressions of p120ctn and VEGF in 100 cases of bladder urothelial carcinoma (bladder cancer) and 40 cases of normal bladder mucosa (normal group) were detected by immunohistochemistry (SP) method. The expressions of Bladder urothelial carcinoma clinical stage, pathological grade relationship. Results The positive rates of p120ctn in bladder cancer and normal controls were 54% and 87.5%, respectively, with statistical significance (P <0.05). The positive rates of VEGF were 93% and 42.5%, respectively, with statistical significance (P < 0.05). The expression of p120ctn and VEGF protein in bladder cancer showed a positive correlation with the pathological type and clinical stage of the tumor. Conclusions The expression of p120ctn and VEGF in bladder carcinogenesis changes and correlates with the pathological grade and clinical stage of the tumor, which may be used as an important index to judge the biological characteristics of bladder cancer.