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非特异性免疫是机体抵抗病原微生物感染的第一道屏障。作为识别病原体并作出迅速反应的蛋白——Toll样受体(TLR)家族发挥着重要的作用。目前已发现TLR家族有10个成员,形成了一个复杂的、联合性网络,特异性地识别大量病原体及组织代谢物等信号识别系统。最近研究显示TLR在肝脏疾病的发生和发展机制中,通过影响TNF、IFN及调节Th1和Th2反应平衡等起到重要作用。鉴此,有必要对TLR在暴发性肝衰竭、病毒性肝炎、酒精性肝病、肝脏损伤及在肝细胞中的表达与调节作用的研究概况予以介绍,以期为进一步研究肝脏疾病的发病机制和防治措施提供科学依据。
Non-specific immunity is the body’s first barrier against pathogenic microbial infections. It plays an important role as a TLR family of proteins that recognize pathogens and respond rapidly. It has been found that TLR family has 10 members, forming a complex, joint network, specifically identifying a large number of pathogens and tissue metabolites and other signal recognition systems. Recent studies have shown that TLR plays an important role in the pathogenesis and development of liver diseases by affecting TNF, IFN and regulating the balance between Th1 and Th2 responses. In view of this, it is necessary to introduce the general situation of TLR in fulminant hepatic failure, viral hepatitis, alcoholic liver disease, liver injury and expression and regulation in hepatocytes. In order to further study the pathogenesis and prevention and treatment of liver disease Measures provide a scientific basis.