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目的比较3种方法治疗未破裂卵泡黄素化综合征(LUFS)疗效。方法将34个病例56个治疗周期随机分成3个治疗组:A组(HCG组),B组(单次GnRH-a组),C组(GnRH-a+HCG组),观察3组患者的妊娠率,排卵率,并分别于HCG/达必佳注射日及排卵后7日抽取外周血测LH,P,观察各组有无差异。结果3种治疗方法的排卵率有统计学差异(P<0.05),C组的排卵率显著高于B组,A组。而3组的妊娠率则无明显差异(P>0.05)。HCG/达必佳注射日3组血LH有统计学差异(P<0.05),C组低于A组与B组,而血P值则3组之间无统计学差异(P>0.05)。排卵后7日血P值3组之间亦有统计学差异(P<0.05),A组高于C组,C组高于B组。结论GnRH-a+HMG方案能有效的降低HCG注射日LH值,提高LUFS患者的排卵率,但妊娠率无明显改善。
Objective To compare the efficacy of three methods in treatment of luteinized unruptured follicle syndrome (LUFS). Methods A total of 56 treatment cycles of 34 cases were randomly divided into three treatment groups: group A (HCG group), group B (group GnRH-a) and group C (group GnRH-a + HCG) Pregnancy rate, ovulation rate, respectively, and HCG / Dabigabee day and ovulation 7 days after the extraction of peripheral blood LH, P, to observe the difference between the groups. Results The ovulation rates of three treatments were statistically different (P <0.05). The ovulation rate of group C was significantly higher than that of group B and group A. There was no significant difference in pregnancy rates among the three groups (P> 0.05). There was a significant difference in LH between HCG / Dabisipexid injection on day 3 and group C (P <0.05), but there was no significant difference between group C and group B (P> 0.05). There was also a significant difference between the three groups on the 7th day after ovulation (P <0.05). A group was higher than C group, C group was higher than B group. Conclusion The GnRH-a + HMG regimen can effectively reduce the LH value on HCG injection day and increase the ovulation rate of LUFS patients, but the pregnancy rate has no significant improvement.