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目的 研究应用微粒化的高纯度香叶木甙 (爱脉朗 )治疗急性痔发作。方法 92例患者参加本研究。随机、双盲的研究计划经伦理委员会批准 ,有书面知情同意。研究组用香叶木甙 ,对照组用安慰剂 ,疗程为 7d。结果 90例患者完成了全过程 ,数据输入电脑后开盲。开盲后研究组为 47例 ,对照组为 43例。在安全性方面两组均未出现全身不良反应 ,也未出现血液系统、肝、肾等脏器功能损害。在第 7天时复查发现 :(1)疼痛症状消失的患者在研究组为 6 8 1% ,对照组为 39 5 % ,2组之间有显著差别 (P =0 0 0 7)。 (2 )水肿体征消失和明显改善的患者在研究组为 95 7% ,对照组为79 1% ,2组之间有显著差别 (P =0 0 16 )。 (3)出血消失的患者在研究组为 89 4% ,对照组为 6 9 8% ,2组之间有显著差别 (P =0 0 2 0 )。结论 香叶木甙与安慰剂相比 ,对于疼痛 ,水肿 ,出血等的疗效有显著差别 ,口服药香叶木甙的治疗痔安全有效
Objective To study the application of micronized high-purity geranyl glycosides (Ai Wan Long) in the treatment of acute hemorrhoids. Methods 92 patients participated in this study. Randomized, double-blind research project approved by Ethics Committee with written informed consent. The study group with geranyl glycosides, the control group with placebo, treatment for 7d. Results 90 patients completed the whole process, the data input into the computer after the blind. In the open group, there were 47 cases in the study group and 43 cases in the control group. In the safety of both groups did not appear systemic adverse reactions, nor the blood system, liver, kidney and other organ dysfunction. On the 7th day, it was found that: (1) There was a significant difference (P = 0 0 0 7) between the two groups in terms of the number of pain disappeared in the study group (681%) and the control group (39.5%). (2) There was a significant difference between the two groups (P = 0.0016) in 957% of the study group and 79.1% of the control group, with disappearance and improvement of edema signs. (3) The bleeding disappeared in the study group was 89.4%, the control group was 69.8%, there was a significant difference between the two groups (P = 0.0020). Conclusion Compared with placebo, the effects of diosmin on pain, edema and hemorrhage are significantly different, and oral administration of xyloside is safe and effective in the treatment of hemorrhoids