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目的探讨2型糖尿病伴骨质疏松的危险因素,为糖尿病患者预防骨质疏松的发生发展,提供科学依据。方法收集2015年6月-2016年6月新疆生产建设兵团医院住院2型糖尿病患者411例,进行双能量X线骨密度检查,2型糖尿病伴骨量异常(骨量减少和骨质疏松)者作为病例组,骨量正常者作为对照组。收集患者一般临床资料及生化指标,运用t检验对两组进行比较,并对相关危险因素进行非条件Logistic回归分析。结果 (1)全部受试者按性别分为女性2型糖尿病组和男性2型糖尿病组,在女性组中:骨质疏松和骨量正常组间年龄、病程、体重指数、血糖、糖化血红蛋白、高密度脂蛋白差异有统计学意义(P<0.05);(2)在男性组中:骨质疏松和骨量正常组间年龄、病程、体重指数、甘油三酯、低密度脂蛋白差异有统计学意义(P<0.05)。(3)多因素非条件logistic回归分析结果显示,在2型糖尿病患者中,年龄、性别、病程、血糖、糖化血红蛋白与其发生骨质疏松的高风险相关(P<0.05);体重指数与其发生骨质疏松低风险相关(P<0.05)。结论年龄、病程、性别、体重指数、血糖、糖化血红蛋白是2型糖尿病发生骨质疏松的独立危险因素,积极控制血糖、血脂、血压及维持合理体重,可延缓2型糖尿病患者骨质疏松的发生及发展。
Objective To explore the risk factors of type 2 diabetes with osteoporosis and provide scientific basis for the prevention and treatment of osteoporosis in diabetic patients. Methods A total of 411 type 2 diabetic patients admitted to the Xinjiang Production and Construction Corps Hospital from June 2015 to June 2016 were enrolled in this study. They were examined by dual energy X-ray absorptiometry and type 2 diabetes with abnormal bone mass (osteopenia and osteoporosis) As a case group, normal bone mass as a control group. The general clinical data and biochemical indexes were collected. The t test was used to compare the two groups, and the non-conditional Logistic regression analysis was conducted on the related risk factors. Results (1) All subjects were divided into female type 2 diabetes and male type 2 diabetes by sex. In the female group, the age, course of disease, body mass index, blood glucose, glycosylated hemoglobin, (2) In the male group, the difference of age, course of disease, body mass index, triglyceride and low density lipoprotein between the osteoporosis group and the normal bone mass group were statistically significant Significance (P <0.05). (3) Multivariate non-conditional logistic regression analysis showed that age, sex, course of disease, blood glucose and HbA1c were associated with high risk of developing osteoporosis in type 2 diabetic patients (P <0.05); body mass index Loosening was associated with low risk (P <0.05). Conclusion Age, disease course, sex, body mass index, blood glucose and HbA1c are independent risk factors of type 2 diabetes. Positive control of blood glucose, blood lipid, blood pressure and maintaining a reasonable weight can delay the occurrence of osteoporosis in type 2 diabetic patients And development.