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神经-血管偶联机制至今还没有完全被阐明.对脑微循环的研究表明,位于皮层内的微动脉的舒张代表着神经-血管偶联过程中的最初血流响应机制.一氧化氮(NO)被认为是介导微动脉舒张的最重要因子之一,为了探讨NO在微动脉舒张过程中作为关键因子的作用,本文开展了基于大脑功能柱水平,由功能刺激产生的NO在神经-血管偶联过程中扩散动力学的时空模式的仿真建模研究.在大脑功能柱形态分析的基础上,建立NO扩散数学模型.应用该模型,清晰地阐述了由功能刺激产生的NO在时间维度和空间维度的扩散过程.计算机仿真结果表明,由功能刺激产生的NO,其扩散主要被限制在功能柱内.因此,NO作用的影响区域也就被限制在功能柱内.在时间维度上,NO信号大约维持1s左右.本研究从四维时空角度探讨由功能刺激产生的血管舒张因子的响应模式,为最终阐明神经-血管偶联机制提供了一种新的途径.
The neuro-vascular coupling mechanism has not yet been completely elucidated.Research on brain microcirculation shows that the relaxation of the arterioles located in the cortex represents the initial blood flow response mechanism in the neuro-vascular coupling process.Nitrogen monoxide (NO ) Is considered as one of the most important factors that mediate the relaxation of arterioles. To explore the role of NO as a key factor in the relaxation of arterioles, we developed a method based on the level of functional brain column, In the process of coupling, the model of diffusion-dynamics in spatio-temporal model was established.On the basis of morphological analysis of functional column of brain, a mathematical model of NO diffusion was established.Using this model, the NO produced by functional stimulation was clearly described in the time dimension and The diffusion process of space dimension.The simulation results show that the diffusion of NO generated by functional stimulation is mainly confined to the functional column.Therefore, the influence area of NO effect is also limited to the functional column.In the time dimension, NO Signal about 1s or so.In this study, four dimensional space-time from the functional stimulation of vasodilator response mode, the final elucidation of neural-vascular coupling mechanism For a new way.