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目的探讨乳腺颗粒细胞瘤的临床病理特征、诊断与鉴别诊断。方法对1例乳腺颗粒细胞瘤进行组织形态学、影像学和免疫组化研究,并复习文献。结果左乳内上象限触及2 cm×2 cm质硬包块。瘤细胞体积大,圆形、多边形或梭形,胞浆丰富嗜酸性颗粒状,呈实性巢团或条索状排列,浸润性生长。抗淀粉酶PAS阳性,免疫组化染色瘤细胞S-100、NSE、Vimentin(+),CK、EMA、myoglobin、ER和PR均(-)。结论乳腺颗粒细胞瘤少见,临床、影像学、细胞学和冷冻快速切片均易误诊或漏诊,确诊主要依靠病理组织学和免疫组化标记。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of granulosa cell tumor of the breast. Methods One case of granulosa cell tumor of the breast was studied by histomorphology, imaging and immunohistochemistry. The literature was reviewed. Results The upper quadrant of the left breast touched a hard mass of 2 cm × 2 cm. Tumor cells are bulky, round, polygonal or fusiform, cytoplasm rich eosinophilic granulocytes, were arranged in solid nest or cords, invasive growth. Immunohistochemical staining of S-100, NSE, Vimentin (+), CK, EMA, myoglobin, ER and PR were all positive for anti-amylase PAS. Conclusions Breast granulosa cell tumor is rare. Clinical, radiological, cytological and frozen sections are easily misdiagnosed or missed. The diagnosis mainly depends on histopathology and immunohistochemistry.