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目的观察β-内酰胺类抗生素在尿毒症患者中的应用情况。方法回顾性分析16例尿毒症应用常规剂量的β-内酰胺类抗生素引起神经精神症状患者的临床资料。结果 16例尿毒症患者中,1例未透析患者停药后自行好转,2例患者停药并血液透析治疗1次后精神症状消失,3例患者停药并血液透析治疗2次后精神症状消失,5例患者停药并血液透析治疗3次后精神症状消失,5例停药并治疗4次后精神症状消失。结论尿毒症患者使用抗生素出现神经精神症状宜及早诊断,及时停止应用抗生素类药,采用血液净化治疗,可取得满意效果。
Objective To observe the application of β-lactam antibiotics in patients with uremia. Methods A retrospective analysis of 16 cases of uremia with conventional doses of β-lactam antibiotics cause neuropsychiatric symptoms in patients with clinical data. Results Of the 16 patients with uremia, 1 patient who did not receive dialysis had self-improvement after discontinuation of medication, 2 patients discontinued medication and disappeared after hemodialysis treatment for 1 time, and 3 patients discontinued and their psychiatric symptoms disappeared after hemodialysis treatment for 2 times , 5 patients discontinued and hemodialysis treatment three times after the disappearance of mental symptoms, 5 cases of withdrawal and treatment of psychiatric symptoms disappear after 4 times. Conclusions Uremic patients should use antibiotics to diagnose their neuropsychiatric symptoms as soon as possible and stop using antibiotics in time. Blood purification treatment can achieve satisfactory results.