论文部分内容阅读
目的探讨冠心病合并抑郁患者的血管内皮功能及临床意义。方法 320例经冠脉造影确诊的冠心病患者根据汉密顿抑郁量表(HAMD)评定,抑郁组192例和非抑郁组128例,所有入选者均接受肱动脉超声检查和血清一氧化氮(NO)、内皮素(ET)浓度测定。结果抑郁组与非抑郁组的冠心病患者FMD%、NMD%、NO、ET比较差别有统计学意义(P<0.05),抑郁组与非抑郁组的冠心病患者冠状动脉Gensini评分比较差别有统计学意义(χ2=5.31,P<0.05),抑郁组与非抑郁组的冠心病患者病情稳定与不稳定的比例比较差别有统计学意义(χ2=19.3,P<0.001)。结论抑郁组的冠心病患者比非抑郁组的冠心病患者血管内皮功能的受损程度严重,冠脉病变狭窄程度严重,病情趋于不稳定。
Objective To investigate the vascular endothelial function in patients with coronary heart disease complicated with depression and its clinical significance. Methods According to the Hamilton Depression Rating Scale (HAMD), 320 patients with coronary heart disease diagnosed by coronary angiography were enrolled. 192 patients in depression group and 128 in non-depression group were enrolled in this study. All patients underwent brachial artery ultrasonography and serum nitric oxide NO), endothelin (ET) concentrations were measured. Results There were significant differences in FMD%, NMD%, NO, ET between the depression group and the non-depression group (P <0.05). The difference of coronary Gensini score between the depression group and the non-depression group was statistically significant (Χ2 = 5.31, P <0.05). There was a significant difference in the proportion of stable and unstable patients between the depression group and the non-depression group (χ2 = 19.3, P <0.001). Conclusion The severity of vascular endothelial dysfunction in patients with coronary heart disease in the depression group is more serious than that in the non-depression group. The degree of coronary artery stenosis is serious and the disease tends to be unstable.