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炎症体是一种多蛋白复合体,能介导IL-1β等多种炎症细胞因子释放,在炎症的发生发展中具有重要的作用。随着对炎症体研究的不断深入,目前已有文献报道炎症体可能参与机械力所诱导的机体炎症性疾病。与此同时,近年来研究显示,机械力可诱导牙周组织发生炎症反应,并伴随IL-1β和caspase-1/-5的表达。然而,炎症体及相关蛋白在力诱导牙周炎症反应中的作用尚不明确。综述炎症体的特点、在力相关炎症性疾病中的作用、机械力诱导的牙周炎症及其与炎症体和相关蛋白关系的研究进展。
Inflammatory body is a multi-protein complex, which can mediate the release of many inflammatory cytokines, such as IL-1β. It plays an important role in the development of inflammation. With the continuous research on inflammasome, it has been reported in the literature that inflammasome may participate in the inflammatory diseases of the body induced by mechanical force. In the meantime, in recent years, studies have shown that mechanical force can induce periodontal tissue inflammation, accompanied by the expression of IL-1β and caspase-1 / -5. However, the role of inflammasomes and related proteins in force-induced periodontal inflammation remains unclear. This review summarizes the characteristics of inflammasomes, their roles in force-related inflammatory diseases, the periodontal inflammation induced by mechanical force, and their relationship with inflammatory and related proteins.