三油酸甘油酯抗胃粘膜损伤及作用机制

来源 :沈阳药科大学学报 | 被引量 : 0次 | 上传用户:huacheng520
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考察了三油酸甘油酯对无水乙醇所致大鼠胃粘膜损伤的保护作用及其对抗aspirin、reser pine所致小鼠胃溃疡的作用 .并进一步探讨了三油酸甘油酯抗溃疡作用的机制 .实验结果表明 ,三油酸甘油酯可降低上述各模型中大鼠及小鼠的溃疡指数 ,其作用是以增强胃的防御因子为主 .主要机制研究表明 ,三油酸甘油酯是通过促进胃内前列腺素E2 (PGE2 )和粘液的合成及分泌而起到保护胃粘膜的作用 The protective effect of triolein on rat gastric mucosal injury induced by ethanol and its effect on gastric ulcer induced by aspirin and reser pine in mice were also investigated.The anti-ulcer effect of triolein Mechanism.Experimental results show that triolein can reduce the rat and mouse ulcer index in the above models and its role is to enhance the gastric defensive factor based mechanism studies have shown that triolein by Promote gastric prostaglandin E2 (PGE2) and mucus synthesis and secretion and play a role in protecting the gastric mucosa
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