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目的观察中西医结合治疗对肾功能不全患者血清血管内皮细胞生长因子(VEGF)、可溶性血管细胞黏附分子-1(sVCAM-1)表达的影响。方法患者40例随机分为两组,西药组予西医常规治疗,中西药组在此基础上加用中药内服、灌肠;比较两组治疗前后肾功能、血清VEGF、sVCAM-1的水平。结果两组患者症状、肾功能均改善,中西药组VEGF的表达水平升高、sVCAM-1的表达水平降低,优于西药组。结论中西医结合治疗能升高VEGF的表达水平、降低sVCAM-1的表达水平,可能为其改善肾功能、提高临床疗效的机制之一。
Objective To observe the effect of integrated traditional Chinese and western medicine on the expression of serum vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with renal insufficiency. Methods Forty patients were randomly divided into two groups. The western medicine group was given routine western medicine treatment. The western medicine group was treated with traditional Chinese medicine orally and enema on this basis. The levels of serum VEGF and sVCAM-1 were compared between the two groups before and after treatment. Results The symptoms and renal function of both groups were improved. The expression of VEGF and sVCAM-1 in Chinese and Western medicine groups were significantly lower than those in western medicine group. Conclusion The combination of TCM and WM can increase the expression of VEGF and decrease the expression of sVCAM-1, which may be one of the mechanisms to improve renal function and improve clinical efficacy.