肿瘤溶解综合征(TLS)是急性白血病或实体瘤强烈化疗所引起的一种以电解质紊乱为特征的、可危及生命的治疗并发症。常表现为高血钾、酸血症、高尿酸血症、高磷血症、低钙血症及肾功能衰竭。现报道所遇2例血液系统恶性疾患化疗诱发TLS患者的临床诊治经过。 病例介绍 例1 男,14岁。发热伴颈部淋巴结肿大1月余,经青、链霉素治疗无明显好转。1995年4月12日,经左颈部淋巴结活检为B细胞恶性淋巴瘤.于4月18日住院。体检:轻度贫血貌。颈、腋、腹股沟部多 Tumor lysis syndrome (TLS) is a life-threatening therapeutic complication characterized by electrolyte disturbance caused by strong chemotherapy in acute leukemia or solid tumors. Often presents with hyperkalemia, acidemia, hyperuricemia, hyperphosphatemia, hypocalcemia, and renal failure. The clinical diagnosis and treatment of patients with TLS induced by chemotherapy-induced hematologic malignancy are reported. Case Introduction Example 1 Male, 14 years old. Fever with more than 1 month of cervical lymphadenopathy, no significant improvement after treatment with streptomycin. On April 12, 1995, the left cervical lymph node biopsy was B-cell lymphoma. He was hospitalized on April 18. Physical examination: Mild anaemia appearance. Neck, ankle, groin