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目的 在海拔 376 0m的西藏拉萨研究促甲状腺素释放激素 (TRH)对高原创伤性休克合并肺水肿的急进高原大鼠的治疗作用。方法 初进高原大鼠 35只 ,均分为 5组 :假手术对照组 ,失血性休克组 ,失血休克 +肺水肿组 ,失血性休克 +肺水肿+TRH治疗组 ,失血性休克 +肺水肿 +等容量平衡盐液组。大鼠从股动脉放血至血压 (MAP) 5 0mmHg ,5 μL/10 0 g油酸iv ,维持 1h ,制造失血性休克合并肺水肿模型。观察治疗后 15 ,30 ,6 0 ,12 0min的血流动力学指标变化 ,30和 12 0min的血气指标变化以及 12 0min肺脑含水量变化。结果 5mg/kgTRH有良好的抗休克作用 ,给药后MAP升高 ,血流动力学指标改善 ,酸碱平衡紊乱减轻。肺湿 /干重比减少。结论 TRH对并发肺水肿的高原失血性休克大鼠有良好的抗休克及减轻肺水肿的作用
Objective To investigate the therapeutic effect of thyrotropin-releasing hormone (TRH) on acute plateau rats with traumatic shock and pulmonary edema at altitude of 3760m in Lhasa, Tibet. Methods Thirty-five rats were randomly divided into five groups: sham operation control group, hemorrhagic shock group, hemorrhagic shock + pulmonary edema group, hemorrhagic shock + pulmonary edema + TRH treatment group, hemorrhagic shock + pulmonary edema + Equal volume balance salt solution group. Rats were bled from the femoral artery to a blood pressure (MAP) of 50 mmHg and 5 μL / 100 g of oleic acid for 1 hour to manufacture a model of hemorrhagic shock complicated with pulmonary edema. The change of hemodynamics at 15, 30, 60, 120 minutes after treatment, the change of blood gas at 30 and 120 minutes and the change of pulmonary water content at 120 minutes were observed. Results 5mg / kg TRH had a good anti-shock effect, increased MAP after administration, hemodynamic parameters improved, acid-base balance disorders alleviate. Lung wet / dry weight ratio decreased. Conclusions TRH has a good anti-shock and anti-pulmonary edema effect on plateau hemorrhagic shock rats with pulmonary edema