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目的观察妊娠相关血浆蛋白A(PAPP-A)和白介素6(IL-6)在高血压前期(PH)合并IGT患者中的水平变化,并探讨其之间的关系。方法入选PH患者100例,其中合并IGT(PH+IGT)者50例,糖耐量正常(PH+NGT)者50例。采用ELISA法测血浆中PAPP-A、IL-6含量。结果 PH+IGT组PAPP-A和IL-6水平高于PH+NGT组[PAPP-A(12.43±3.65)vs(9.50±3.39)mU/L,IL-6(101.64±19.13)vs(87.56±17.32)ng/L,P<0.05]。多因素Logistic回归分析显示,PAPP-A和IL-6是IGT合并PH的部分危险因素。结论 PH合并IGT患者PAPP-A和IL-6水平增高。
Objective To observe the changes of pregnancy-associated plasma protein A (PAPP-A) and interleukin-6 (IL-6) in patients with prehypertension (PH) complicated by IGT and to explore their relationship. Methods One hundred patients with PH were enrolled in this study. Among them, 50 cases were complicated with IGT (PH + IGT) and 50 cases were with normal glucose tolerance (PH + NGT). The plasma levels of PAPP-A and IL-6 were measured by ELISA. Results The levels of PAPP-A and IL-6 in PH + IGT group were significantly higher than those in PH + NGT group [PAPP-A (12.43 ± 3.65) vs (9.50 ± 3.39) mU / L vs (101.64 ± 19.13 vs 87.56 ± 17.32) ng / L, P <0.05]. Multivariate logistic regression analysis showed that PAPP-A and IL-6 were some risk factors for IGT combined with PH. Conclusion The levels of PAPP-A and IL-6 in patients with PH complicated with IGT increased.