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目的 探讨增殖细胞核抗原 (PCNA)表达与中耳癌发生、发展的关系。方法 应用免疫组化技术对中耳鳞癌、中耳炎性组织和正常鼓膜中的PCNA表达进行检测。结果 ①PCNA在中耳鳞癌中的表达显著高于异型增生 (P <0 .0 1) ;②单纯炎性肉芽和正常鼓膜PCNA表达阴性 ;③PCNA表达指数与中耳癌分化程度负相关。癌组织分化越差 ,PCNA指数越高 ,相差有显著意义 (P <0 .0 5) ;④PCNA指数与中耳癌临床分期无关。结论 PCNA高表达与中耳癌发生及生物学行为不良相关
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and the occurrence and development of middle ear carcinoma. Methods Immunohistochemistry was used to detect the expression of PCNA in squamous cell carcinoma of middle ear, middle ear inflammatory tissue and normal eardrum. Results ① The expression of PCNA was significantly higher in squamous cell carcinoma of middle ear than in dysplasia (P <0.01). ② The expression of PCNA was negative in granuloma and normal tympanic membrane; ③ The expression of PCNA was negatively correlated with the degree of differentiation of middle ear. The worse the differentiation of cancer tissue, the higher the PCNA index, the difference was significant (P <0.05); ④PCNA index had no correlation with the clinical stage of middle ear carcinoma. Conclusion The high expression of PCNA is associated with the development of middle ear carcinoma and poor biological behavior